Three times in Romans chapter 1 Paul states that God gave them up! Abandoned by God to a heart without God, a soul without God and a mind without God. We need God for meaning, truth and satisfaction. Rejecting God in our sin is a big mistake. At times God backs off and leaves us to our own devices. When God gives us up it is an ever decreasing spiral, a race to the bottom of moral depravity and despair.
Dr J Stewart Gillespie